颈动脉粥样硬化斑块炎性反应程度与血清胆红素水平的相关性研究

摘要

Objective To study the association between inflammatory reaction and serum bilirubin level in patients with carotid atherosclerotic plaques .Methods Thirty carotid atherosclerosis pa‐tients were included in this study .The TBR for local reflex activity in their carotid atherosclerotic plaques was calculated and the inflammatory reaction in their carotid atherosclerotic plaques was assayed by PET .Their serum levels of bilirubin (direct and indirect bilirubin)and other cardiovas‐cular risk factors were measured by biochemical analysis .The association between inflammatory reaction and serum bilirubin level in carotid atherosclerotic plaques was analyzed by Pearson cor‐relation analysis and multivariate linear regression analysis ,respectively .Results Pearson corre‐lation analysis showed that the TBR was positively associated with BMI and serum levels of apoB ,apoB/apo A‐Ⅰ ,and direct bilirubin in carotid atherosclerotic plaques (r= -0 .380 ,P=0.038;r=0 .392 ,P=0 .032 ;r= -0 .534 ,P=0 .002;r= -0 .535 ,P=0 .002 ) .M ultivariate linear regression analysis revealed that the TBR was associated with direct bilirubin alone (β= -0 .257 , P=0 .002 ) .Conclusion Serum direct bilirubin level is independently and negatively associated with inflammatory reaction in carotid atherosclerotic plaques .%目的：探讨颈动脉粥样硬化斑块炎性反应程度与血清胆红素水平的相关性及临床意义。方法选取颈动脉粥样硬化患者30例，应用正电子发射断层显像，计算颈动脉斑块局部反射性活度标准化靶‐本底比，定量患者颈动脉粥样硬化斑块的炎性反应程度；通过全自动生化分析仪检测其血清总胆红素、直接胆红素、间接胆红素和其他心脑血管的危险因素指标。采用Pearson相关分析及多重线性回归分析患者颈动脉粥样硬化斑块炎性反应程度与血清胆红素水平的相关性。结果 Pearson相关分析显示，患者颈动脉斑块反射性活度标准化靶‐本底比值与体质量指数（ r＝－0．380，P＝0．038）、载脂蛋白B （ r＝0．392，P＝0．032）、载脂蛋白B／载脂蛋白A‐Ⅰ（ r＝－0．534，P＝0.002）和直接胆红素（ r＝－0．535，P＝0.002）存在相关性。多重线性回归分析校正相关危险因素后，反射性活度标准化靶‐本底比值仅与直接胆红素相关（β＝－0．257，P＝0.002）。结论血清中直接胆红素水平与颈动脉斑块的炎性程度存在独立的负性相关性。