内皮素-1在炎症性肠病发病中作用的研究进展

摘要

炎症性肠病（IBD）是一种病因尚未完全明确的慢性非特异性肠道炎性疾病，包括克罗恩病（CD）和溃疡性结肠炎（UC）。内皮素-1（ET-1）是一种由21个氨基酸残基组成的活性多肽，具有较强的收缩力，可通过活化血管平滑肌的电位依赖性钙离子通道发挥收缩血管作用。研究显示 ET-1在 IBD 的发生、发展中发挥重要作用。本文就 ET-1在 IBD 发病中作用的研究进展作一综述。%Inflammatory bowel disease(IBD)is a kind of chronic and non-specific inflammatory disease comprising Crohn’s disease(CD)and ulcerative colitis(UC),the etiology has not yet been clarified. Endothelin-1(ET-1)is an active polypeptide composed of 21 amino acid residues,which can constrict blood vessels by activating voltage-dependent Ca2 + channels in vascular smooth muscle cells. Studies have shown that ET-1 plays an important role in the pathogenesis of IBD. This article reviewed the progress in study on ET-1 in the pathogenesis of IBD.