MTSS1和Hpa在结肠癌中的表达及其临床意义

摘要

Objective To investigate the expression of MTSS1 and Hpa in colon cancer,and to analyze the correlation of MTSS1 and Hpa with invasion and metastasis of colon cancer. Methods The immunohistochemistry was used to detect the expression of MTSS1 and Hpa in 60 cases with colon cancer. The relationship between expressions of proteins and clinicopathologic factors was evaluated. Results The positive expression rate of MTSS1 was 18.3% in cancer tissues. MTSS1 expression and differentiation of colon cancer, lymph node switch, TNM stage were significant correlation colon cancer. Hpa was 55. 0% (33/60) in cancer tissues. The expression of MTSS1 and Hpa were associated with tumor stage and lymph node metastasis (P <0. 05) , but not with age and gender. Conclusion Both MTSS1 and Hpa play important roles in the development of colon cancer, and the joint test of them could be used as indicators of malignancy and prognosis for colon cancer.%目的 研究转移抑制基因MTSS1及乙酰肝素酶Hpa在结肠癌组织中的表达水平,并探讨两者与结肠癌临床病理特征的关系.方法 应用免疫组化EnVision法检测 60 例原发性结肠癌组织中MTSS1及Hpa蛋白的表达.结果 MTSS1在结肠癌组织中阳性表达率为18.3%(11/60),在肿瘤分期、有无淋巴结转移差异具有统计学意义(P<0.05),在结肠癌肿瘤不同组织学分型的表达差异无统计学意义(P>0.05);Hpa在结肠癌组织中阳性表达率为55.0% (33/60),与肿瘤分期、有无淋巴结转移比较差异有统计学意义(P<0.05),在结肠癌肿瘤不同组织学分型的表达差异无统计学意义(P>0.05).结论 MTSS1及Hpa的表达与结肠癌的浸润、转移密切相关,联合检测MTSS1及Hpa的表达水平对判断结肠癌恶性程度和预后具有一定的参考价值.