肠道菌群与非酒精性脂肪性肝病关系的研究进展

摘要

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease in Western countries and some Asian countries,and currently the incidence of NAFLD continues to increase worldwide. NAFLD encompasses a pathologic spectrum of disease, from relatively benign accumulation of lipid (steatosis) to progressive non-alcoholic steatohepatitis(NASH) associated with inflammation,fibrosis,necrosis and hepatocellular carcinoma. Without an effec-tive available treatment,the prognosis of NASH is poor due to the high risk of progressive liver diseases such as cirrhosis and carcinoma,making it a great burden in health worldwide. NAFLD is a multifactorial disease, apart from environ-mental and genetical factors, recent studies suggest that gut microbiota might be implicated in the pathogenesis of NAFLD. Here,the relationship between gut microbiota and NAFLD was reviewed.%非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是西方国家及一些亚洲国家中常见的慢性肝脏疾病,目前在世界范围内的发病率逐渐上升.NAFLD包括单纯性脂肪肝、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis, NASH)、NASH相关性肝硬化及肝癌等一系列疾病.NASH进展为肝硬化、肝癌的风险大,预后差,是世界范围内沉重的医疗负担.NAFLD是由多种因素引起的疾病,除了环境因素及遗传因素外,近年来不断有证据提示,肠道菌群在NAFLD的发生、发展过程中起一定作用,本文就肠道菌群与NAFLD关系的研究进展作一概述.