Objective: To investigate epidemiological features of birth defects and provide a seientific dada for working out interventions measures.Methods: According to National Birth Defect Monitoring Program, a total of 11 815 fetuses and newborns aged from 13 weeks of gestation to 7 days of age in Beijing Tongren Hospital were monitored for birth defects in the last five years.The incidence of birth defects and their categories, constituent ratio and risk factors were evaluated.Results: The cumulative incidence of birth defects was 16.59 ‰ ( 196/11 815), which increased year by year.The top five diseases were malformations involving in the cardiac and vascular, nervous, motor, urinary and alimentary systems.Sixty -five women underwent therapeutic abortion.The occurrence of birth defects mostly combined with the advanced maternal age ( over 35 years old), living in poor environment during early gestation and so on.Conclusion: Preconception and prenatal care should be strengthened.And prenatal screening and diagnosis should be promoted to reduce the occunrence of birth defects.%目的:了解本地区出生缺陷发生率、种类及相关因素,为制定干预措施提供依据.方法:按照国家出生缺陷监测方案,对近5年本院分娩的妊娠13周～产后7d的11 815例胎、婴儿进行监测,统计并比较出生缺陷发生率、类别、构成比,分析发病因素.结果:共发现出生缺陷儿196例(16.59%0),5年间发生率呈逐年上升趋势.出生缺陷的主要顺位为循环系统、神经系统、运动系统、泌尿和消化系统缺陷,共治疗性引产65例.可能致畸因素包括孕妇高龄(≥35岁)及居住环境不良等.结论:应加强孕前一围孕期保健及产前筛查和诊断,从而减少出生缺陷的发生.
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