目的 探讨术前准备过程中就开始强化胰岛素治疗对体外循环(CPB)心脏瓣膜置换术炎性介质的影响,及其减轻术后全身炎症反应的机制.方法 40例非糖尿病CPB下心脏瓣膜置换手术患者随机分为常规治疗组(常规组,n=20)和强化胰岛素治疗组(强化组,n=20).强化组患者术中血糖控制在3.9~10.0 mmol/L,术后控制在4.4~8.3 mmol/L;常规组患者术前、后没有胰岛素治疗.分别于麻醉诱导(T1)、CPB开始后(T2)及CPB结束即刻(T3)、6 h(T4)、12 h(T5)、24 h(T6)和48 h(T7)测定两组患者的血浆胰岛素、白介素(IL)-1β、IL-6、IL-10和肿瘤坏死因子α(TNF-α)水平,并记录患者的预后情况进行比较分析.结果 两组胰岛素水平在CPB开始后上升,于CPB结束时达高峰,随后下降;强化组胰岛素水平从CPB后显著高于常规组(P＜0.05或P＜0.01).两组TNF-α和IL-1β、IL-6水平在CPB开始后上升,CPB后6 h达高峰,随后下降;强化组TNF-α和IL-1β、IL-6水平从CPB后开始显著低于常规组(P＜0.05或P＜0.01).两组IL-10水平在CPB结束时上升,于CPB 12 h达高峰,CPB开始后对照组 IL-10水平始终低于强化组(P＜0.05或P＜0.01).与常规组相比,强化组治疗明显缩短了患者呼吸机辅助通气时间和术后ICU停留时间(P＜0.05),两组院内感染率和病死率无显著差异.结论 强化胰岛素治疗减弱心脏瓣膜置换患者的 TNF-α和IL-1β、IL-6的表达,起到调节全身炎症反应的作用,可以缩短患者呼吸机辅助通气时间和术后ICU停留时间.%Objective To investigate the effects and mechanisms of intensive insulin therapy on inflammatory mediators in the patients underwent heart valve replacement surgery with cardiopulmonary bypass ( CPB ). Methods 40 non - diabetic in - patients underwent valve replacement surgery were randomly assigned to the control group and the intensive insulin therapy group ( IT group ). Perioperative plasma cytokine levels were monitored. Results Compared to the control group, the IT group showed a smaller rise in plasma TNF -α, IL - 1 β, IL-6 levels and a more pronounced rise in IL - 10 levels after initiation of CPB. After surgery, in the IT group, the time of artificial ventilation and postoperative length of stay in the hospital were markedly shortened. However, there were no significant differences in mortality and the nosocomial deep sternal wound infection rate between the IT and control groups. Conclusion Intensive insulin therapy could significantly attenuate the systemic inflammatory response, improve the prognosis, but can not reduce the in - hospital mortality.
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