IL-6基因单核苷酸多态性与中国汉族人群乙型肝炎易感性的相关性研究

摘要

目的 白细胞介素-6(IL-6)在慢性病毒性肝炎发病机制和相关的肝脏疾病中有重要的作用,本文拟通过大样本病例-对照研究以及临床数据分析探讨IL-6单核苷酸多态性与HBV感染易感性的相关性,从而达到能够通过检测机体IL-6基因的表达的水平来预防和治疗HBV感染的目的.方法 选取深圳地区汉族HBV病患者共计848例,对照组894例,抽提基因组DNA,运用TaqMan探针的技术对上述标本的rs1 800 796位点进行基因分型.结果 rs1 800 796位点的单核苷酸多态性与HBV感染的易感性相关P=0.0003,OR=1.43,两者之间的差异具有统计学意义.结论 IL-6rs1800 796位点的单核苷酸多态性与汉族人群HBV感染的易感性相关.%Objective Leukocyte mediated IL-6 (IL-6) plays an important role in chronic viral hepatitis pathogenesis and related liver diseases,We did a large sample-size case-control study and clinical data analysis to find association between IL-6 single nucleotide polymorphism and HBV susceptibility,and to achieve the detection of the body on the expression of IL-6 for the prevention and treatment of HBV infection.Methods Totally 848 HBV patients and 894 healthy controls in Shenzhen were selected and rs1800796 genotypes were determined by TaqMan assays.Results The result showed that rs1800796 polymorphism was associated with susceptibility to HBV infection (P =0.0003,odds ratio (OR) =1.43,the difference was statistically significant.Conclusions The single nucleotide polymorphism of IL-6rs1800796 locus was associated with the susceptibility of HBV infection in Chinese population,and the rs1800796 G allele is a protective gene for HBV infection.