Objective To study the subject domain knowledge of interventional diagnosis and therapy of congenital heart disease ( CHD ) in our country using multiple statistical and social network analysis, and finally build visualized knowledge-mapping. Methods The China Biology Medicine disc ( CBM ) using MeSH keywords " heart defect, congenital" and " cardiac catheterization" in March 2011 was searched. After core keywords had been characterized by Endnote X4, the co-occurrence matrix was built. Transformation, dimensionality reduction and clustering of the co-occurrence matrix were finished by SPSS 17. 0 software, leading the strategic plot to be built. Then visualized network was drawn using Ucinet 6. 0 software. Results The searching results included 1 015 articles, which were imported into Endnote X4 software. The visualized domain knowledge-mapping was successfully built, and it directly reflected the structure of knowledge-mapping of the subject. And key clusters were formed, in which the " therapy", " method and instrument" and " echocardiography" clusters had been developed well. Conclusions The "therapy" cluster stands in the center of the subject domain knowledge-mapping and is well developed with several clusters following. And the study of the " method and instrument" cluster makes a great contribution to the progress of the subject. The studies of echocardiography and pulmonary artery hypertension play an important role in the structure of the knowledge-mapping.%目的 通过多元统计和社会网络分析法中关键词共现的方式,研究中国先天性心脏病（CHD）介入诊断治疗的学科知识分布,研究学科知识聚类,并预测未来发展趋势.方法 2011年3月以主题词”心脏缺损,先天性”和”心脏导管插入术”在中国生物医学文献数据库(CBM)检索文献;使用Endnote X4软件提取关键词,建立共词矩阵；使用SPSS 17.0软件对共现矩阵进行转换、降维和聚类分析,并根据聚类分析结果绘制战略坐标图；使用Ucinet 6.0软件绘制可视化网络.结果 共命中文献1015篇.成功建立中国CHD介入诊断治疗学科知识可视化图谱,直观展示了中国CHD介入诊断治疗学科的知识分布,并形成重点研究聚类,提示治疗,方法和设备,超声心动图等学科知识发展较好.结论 中国CHD学科知识以治疗聚类为中心,且多学科知识聚类共同发展；同时材料和设备的相关研究在CHD学科发展中具有显著推动作用,超声心动图及肺动脉高压在CHD学科知识中地位重要.
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