Objective To investigate the effect of non invasive positive pressure ventilation on plasma high sensitive C-reactive protein(hs-CRP) and N-terminal pro brain natriuretic peptide (NT-pro BNP) of acute exacerbations of chronic ob-structive pulmonary disease ( AECOPD) combined with pulmonary heart disease .Methods 80 cases of patients with pulmo-nary heart disease with AECOPD were randomly divided into 2 groups, 40 cases in each group, the control group received rou-tine treatment of anti infection and cough , expectorant , based on these treatment , the observation group combined the use of noninvasive positive pressure ventilation therapy , 10 d as 1 course of treatment , compared 2 groups'before and after treatment of blood gas analysis and plasma hs-CRP and NT-proBNP levels.Results Observation group after treatment , blood pH, PaO2, PaCO2 and SaO2 were (7.42 ±0.06), (70.02 ±3.66) mm Hg, (61.34 ±4.31) mm Hg and (92.55 ±4.83)%respectively, compared with those before treatment of (7.20 ±0.05), (48.67 ±3.48) mm Hg, (88.94 ±4.43) mm Hg and (79.83 ±3.64)%, these indexes was significantly improved ( P <0.05), and the degree of improvement is better than the control group after treatment of (7.28 ±0.05), (58.90 ±3.74) mm Hg, (72.66 ±4.43) mm Hg and (81.32 ±4.17)%(P <0.05);the observation group after treatment , the plasma hs-CRP and NT-proBNP levels were (7.36 ±1.02) ng/L and (112.80 ±10.03) ng/L, these indexes were lower than before treatment (28.10 ±2.36) ng/L and (280.73 ±13.23) ng/L, these indexes was significantly reduced ( P <0.05), and the extent of decrease was better than the control group after treatment of (14.44 ±1.63) ng/L and (175.61 ±10.87) ng/L ( P <0.05).Conclusion Noninvasive positive pressure ventilation in the treatment of AECOPD with pulmonary heart disease has significantly curative effect , it can significantly re-duce the plasma hs-CRP and NT-proBNP level, and has good clinical application value .%目的：探讨无创正压通气对慢性阻塞性肺疾病急性加重（ AECOPD ）合并肺源性心脏病患者血气分析、血浆高敏C反应蛋白（ hs-CRP）和N-末端脑钠肽前体（ NT-proBNP）的影响。方法将80例AECOPD合并肺心病患者采用数字表法随机分为2组，每组各40例，其中对照组给予抗感染、止咳、祛痰等常规治疗，观察组在此基础上加用无创正压机械通气治疗，10 d为1个疗程，比较2组治疗前后血气分析及血浆hs-CRP和NT-proBNP水平变化。结果观察组治疗后血液pH值、PaO2、PaCO2和SaO2分别为（7．42±0．06）、（70．02±3．66）mm Hg、（61．34±4．31）mm Hg和（92．55±4．83）％，较治疗前的（7．20±0．05）、（48．67±3．48） mm Hg、（88．94±4．43） mm Hg 和（79．83±3．64）％均显著改善（ P ＜0．05），且改善程度优于对照组治疗后的（7．28±0．05）、（58．90±3．74）mm Hg、（72．66±4．43）mm Hg和（81．32±4．17）％（ P ＜0．05）；观察组治疗后血浆hs-CRP和NT-proBNP水平分别为（7．36±1．02）ng/L和（112．80±10．03）ng/L，均较治疗前的（28．10±2．36）ng/L和（280．73±13．23）ng/L显著降低（ P ＜0．05），且降低程度优于对照组治疗后的（14．44±1．63） ng/L和（175．61±10．87） ng/L （ P ＜0．05）。结论无创正压通气治疗AECOPD合并肺心病疗效显著，可明显降低患者血浆hs-CRP和NT-proBNP水平，具有较好的临床应用价值。
展开▼
