Objective To observe the effect of bronchoscope argon plasma coagulation resection ( APC) combined with CO2 cryotherapy in treatment of tuberculous airway stenosis and its impact on the clinical effect of the airway, blood gas a-nalysis, pulmonary function.Methods Select from 2014 June to 2015 June, 144 cases of tuberculous airway stenosis in Shanghai Tongji Hospital as the research group, they were randomly divided into observation group and control group with 72 cases in each group.2 groups of patients were given conventional inhalation, anti-TB drugs, local injection therapy, the con-trol group were received bronchoscopy APC treatment, the observation group also combined CO2 cryotherapy, once a week.2 groups of patients were treatment for 6 months.2 groups of patients before and after treatment, airway diameter, shortness of breath level, KPS score, changes PaCO2 , PaO2 , SpO2 and FEV1/FVC and adverse reactions were recorded.Results Obser-vation group’s total effective rate was 91.7%, which was significantly higher than the 75.0%of control group ( P <0.05);compared with before treatment, after treatment, the two groups of patients’ airway diameter, KPS score, PaO2 , SpO2 , FEV1/FVC significantly increased, shortness of breath grade, PaCO2 significantly decreased ( P <0.05) , wherein the degree of improvement in the observation group were better than the control group ( P <0.05);2 group patients’ active bleeding, fever, oxygen desaturation, mild cough and other adverse symptoms were returned to normal after symptomatic treatment;he-modynamic abnormalities did not occur and other serious adverse reactions were not found.Conclusion Bronchoscopy APC combined with CO2 cryotherapy in treatment of tuberculous airway narrowing’ s effect is obvious and safe, it is advantageous to improve the level of lung function and the quality of life of patients, should be widely applied.%目的：观察支气管镜氩等离子体凝切术（ APC）联合CO2冷冻术治疗结核性大气道狭窄的临床效果及其对气道、动脉血气、肺功能的影响。方法选取2014年6月—2015年6月上海同济医院呼吸科收治的结核性大气道狭窄患者144例为研究对象，随机分为观察组和对照组各72例。2组患者均给予常规雾化吸入、抗结核类药物、局部注药等治疗，对照组采用支气管镜APC治疗，观察组在对照组基础上联合应用CO2冷冻治疗，每周治疗1次。2组患者疗程均6个月。观察2组患者治疗前后气道内径、气促等级、KPS评分、PaCO2、PaO2、SpO2及FEV1／FVC的变化情况，并记录2组患者不良反应。结果治疗后观察组总有效率为91�．7％，显著高于对照组的75．0％（ P ＜0．05）；与治疗前比较，治疗后2组患者气道内径、KPS评分、PaO2、SpO2、FEV1／FVC明显提高，气促等级、PaCO2均显著降低（ P ＜0．05），其中观察组改善程度优于对照组（ P ＜0．05）；2组患者活动性出血、发热、氧饱和度降低、轻度咳嗽等不良症状，经对症处理后恢复正常，均未发生血流动力学异常及其他严重不良反应。结论支气管镜APC联合CO2冷冻术治疗结核性大气道狭窄效果明显，安全性好，有利改善患者肺功能水平，提高患者生存质量，值得推广应用。
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