Objective To investigate the clinical efficacy of bronchoscopic cryotherapy (CO2 ) combined with argon knife for treating tuberculosis(TB) airway stenosis .Methods 150 cases of TB airway stenosis in our depart‐ment from March 2010 to June 2013 were selected and divided into 3 groups according to the hospitalization order:the control group 1 ,control group 2 and the study group .The 3 groups were treated by anti‐TB drugs ,aerosol inhalation , topical injection of drugs ;the control group 1 (50 cases) was given the argon knife therapy ;the control group 2 (50 cases) was given the cryotherapy ;the study group(50 cases) was treated with bronchoscopic interventional cryother‐apy combined with argon knife .The total course of treatment was 6 months .The clinical effects in 3 groups were per‐formed the comparative analysis .Results The relief rate after treatment in the study group was 94 .0% ,which was significantly superior to 70 .0% and 64 .0% in the control group 1 and 2 ,the differences among them showed the sta‐tistical significance (P<0 .05) .Meanwhile ,the tracheal internal diameter and FEV1/FVC values in the study group were significantly improved compared with the control group 1 and 2 ,the difference had statistical significance(P<0 .05) .Conclusion The bronchoscopic cryotherapy combined with argon knife has better clinical effect for treating tuberculosis airway stenosis ,at the same time has high safety without serious complications and with high clinical promotion value .%目的：探讨经支气管镜二氧化碳（CO2）冷冻联合氩气刀治疗结核性大气道狭窄的临床疗效。方法选取2010年3月至2013年6月收治的结核性大气道狭窄患者150例，按患者住院顺序分为3个组，对照1组、对照2组和研究组。3个组患者均应用抗结核药物、雾化吸入、局部注药；对照1组：50例，给予氩气刀治疗；对照2组：50例，给予冷冻治疗；研究组：50例，则给予支气管镜介入冷冻联合氩气刀治疗。3个组总疗程6个月。并对3个组临床治疗效果进行对比分析。结果3个组患者的经治疗后，研究组的缓解率为94．0％，明显优于对照1组的70．0％和对照2组的64．0％，组间差异有统计学意义（ P＜0．05）。同时，研究组患者气管内径及 FEV1／FVC比值也较对照1组、对照2组明显改善，差异有统计学意义（P＜0．05）。结论经支气管镜冷冻联合氩气刀进行结核性大气道狭窄治疗具有较好的临床治疗效果，同时安全性高，无严重并发症，具有较高的临床推广价值。
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