氯沙坦对实验性糖尿病大鼠尿白蛋白排泄的影响

摘要

Objective　To observe the effect of losartan on urinary albumin excretion in streptozotocin diabetic rats.Methods　The following groups of rats were studied:normal control rats(NC),diabetic control rats (DC),diabetic rats treated with losartan 〔20mg/(kg*d)〕(DL) and diabetic rats treated with perindopril （2mg/(kg*d)〕(DP).Urinary albumin was observed at the 4th、8th、12th and 16th week.Results　Urinary albumin excretion of diabetic rats treated with losartan or perindopril were significantly lower than that of diabetic untreated group (P＜0.01).The effect was not different between losartan treated and perindopril treated rats.Conclusion　The results suggested that losartan can reduce urinary albumin excretion in diabetic rats.%目的观察血管紧张素受体拮抗剂氯沙坦(losartan)对糖尿病大鼠尿白蛋白排泄的影响。方法雄性SD大鼠分为正常对照组(NC)、糖尿病对照组(DC)、糖尿病氯沙坦治疗组(DL)和糖尿病培哚普利治疗组(DP)。检测各组第4、8、12、16周尿白蛋白排泄的变化。结果 DL组较DC组尿白蛋白排泄显著下降(P＜0.01)，和DP组比较无显著性差异。结论血管紧张素受体拮抗剂氯沙坦能有效降低糖尿病大鼠尿白蛋白的排泄。