ICA、64KDAb、IAA联合检测在1型糖尿病一级亲属中的预测价值

摘要

目的为研究ICA、64KDAb、IAA对1型糖尿病患者非糖尿病一级亲属的预测价值，对1型糖尿病患者及其非糖尿病一级亲属与普通人群中胰岛素自身抗体的分布情况进行了测定。方法①胰岛细胞抗体和谷氨酸脱羧酶抗体采用ELISA法测定。②血清胰岛素自身抗体采用放射免疫分析法测定。结果 ICA、64KDAb、IAA在1型糖尿病患者及其一级亲属中阳性率明显高于普通人群，64KDAb阳性率高于ICA、IAA。结论 64KDAb较ICA、IAA具有更高的敏感性，预示1型糖尿病的标志。ICA、64KDAb、IAA三者联合检测可提高糖尿病的预测价值。%Objective　To study the predictive value of islet cell antibody (ICA),64KD protein antibody(64KDAb) and insulin auto-antibody (IAA) in the first-degree relatives of type 1 diabetics.Methods　The determination of islet autoantibody distribution in type 1 diabetes patients,first-degree relatives without diabetes and normal individuals was made.Results　The results revealed that ICA and 64KDAb positive rate in type I diabetes patients and their first-degree relatives was significantly higher than normal individuals.The positive rate of 64KDAb is higher than that of ICA and IAA. Conclusion　These results suggest that 64KDAb's sensitivity is higher than ICA and IAA's,so 64KDAb is more valuable as the marker of predicting type 1 diabetes.The combined determination of ICA,64KDAb and IAA might improve the value for predicting diabetes.