血浆糖化低密度脂蛋白、脂蛋白(α)与2 型糖尿病大血管病变的关系

摘要

目的 观察2型糖尿病病人血浆糖化低密度脂蛋白(糖化LDL)、脂蛋白(α)[Lp(α)]浓度与大血管病变的关系。方法对56例2型糖尿病病人(28例并发大血管病变，28例无血管病变)和48例健康人分别采用氯化硝基四唑氮蓝还原比色法和ELISA法测定了血浆糖化LDL和Lp(α)。结果2型糖尿病并发大血管病变组糖化LDL、Lp(α)浓度显著升高，糖化LDL浓度与Lp(α)浓度无显著相关性。结论糖化LDL、Lp(α)浓度升高是2型糖尿病大血管病变的危险因素，但同时又是相互独立的危险因素。%ObjectiveIn order to study the relationship between the variation of concentration of plasmaglycosylated low density lipoprotein (glycated LDL) and lipoprotein (α) [Lp (α)] and macroangiopathy in type 2 diabetesmellitus patients.Methods Plasma glycated LDL was measured with nitroblue tetrazolium reduction method and Lp(α)was measured with ELISA method in 56 cases of type 2 DM patients including 28 with macroangiopathy and 28 withoutangiopathy and 48 healthy objects.Results The levels of glycated LDL and Lp (α) in type 2 DM patients withmacroangiopathy were significantly higher than those without angiopathy.There was no correlation between plasmaglycated LDL and Lp(α) in type 2 DM patients.Conclusion The high levels of glycated LDL and Lp(α) were riskfactors for the development of macroangiopathy in type 2 DM and meanwhile they were independent factors for type 2DM macroangiopathy.