High and Low Density Lipoprotein Cholesterol in Relation to Whole Blood Viscosity

摘要

We measured whole blood viscosity in a normal population and analyzed results in relation to packed cell volume (hematocrit, PCV), fibrinogen, white blood cell count (WBC), platelet count and plasma lipids including total cholesterol, triglycerides, high density lipoprotein cholesterol (HDLc) and low density lipoprotein cholesterol (LDLc). A strong overall correlation was seen between WBV and PCV (r = 0.78, p<0.001). Significantly positive correlations were found between WBV and cholesterol (r = 0.22, p<0.001), triglycerides (r = 0.14, p<0.001) and LDLc (r = 0.21, p<0.001). A significant negative correlation was found between HDLc and WBV (r = -0.20, p<0.001). However, analysis by sex showed only the correlation of LDLc was significant for both men and women. These data confirm a correlation between WBV and LDLc. WBV deserves further study as a potentially reducible risk factor in groups known to be at risk for heart disease because of abnormally high levels of LDLc.