Objective To study the effects of basal insulin addition on poorly-controlled blood glucose of T2DM patients. Methods Sxty patients were randomized into three groups. They received insulin detemir (Det), glargine (Gla) ,and neutral protamine hagedorn (NPH) respectively at bedtime for 12 weeks. Results , FBG, 2 hBG, and HbA1c of the 3 groups were lower after treatment (P<0. 01), although there was no statistical differences among these 3 groups (P>0. 05), The incidence of hypoglycemia was 5% in the Det and Gla groups, lower than that in the NPH group (P<0. 05). The weight gain was (0. 7 + 0. 34) kg in the Det group, lower than in the Gla group (1. 43+0. 35) kg and in the NPH group (1. 42±0. 32) kg (P<0. 01). There was no statistical differences in insulin dosage and target arrival time of blood glucose among the 3 groups (P>0. 05). Conclusion It is more effective and safer to use Det or Gla than NPH in T2DM patients with the poorly-controlled blood glucose. Det is more superior in weight control%目的 观察基础胰岛素对于口服降糖药(OAD)控制不佳的T2DM的临床疗效和安全性.方法 60例OAD控制不佳的T2DM患者睡前分别加用地特胰岛素(Det)、甘精胰岛素(Gla)和中性鱼精蛋白胰岛素(NPH),每组20例治疗12周.结果 3组FBG、2 hBG、HbA1c均较基线下降(P＜0.01),但组间差异无统计学意义(P＞0.05).Det组和Gla组低血糖发生率均为5％,低于NPH组30％(P＜0.05).Det组体重增加(0.7±0.34) kg,低于Gla组(1.43±0.35) kg和NPH组(1.42±0.32) kg(P＜0.01).3组胰岛素用量和达标时间比较无统计学差异(P＞0.05).结论 对于口服降糖药控制不佳的T2DM患者加用地特或甘精胰岛素更安全:地特胰岛素在体重控制方面更有优势.
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