CD45分子在HIV-1病毒感染中的作用研究进展

摘要

CD45 is a transmembrane molecule with phosphatase activity, and plays a major role in immune cells.CD45 is required for the antigen receptor signal transduction, and attributed as an apoptosis regulator.Impairment of this function may result in autoimmune, immunodeficiency, and malignant diseases.The role of CD45 in HIV-1 infection is one of important research topics.This paper summarizes the research progress on the role of CD45 in HIV-1 infection.%CD45分子是具有磷酸酶活性的跨膜蛋白,在免疫细胞中发挥重要作用.CD45分子对抗原受体信号转导是必需的,并具有调节细胞凋亡的作用,其功能紊乱会导致自身免疫性疾病、免疫缺陷、恶性肿瘤等.CD45分子的结构及其功能与HIV感染之间的关系是艾滋病研究领域的重要内容之一,本文就CD45分子在HIV感染中的作用作一综述.