Objective: To evaluate the efficacy and toxicity of the weekly dose of Nedaplatin combined with radiation for esopha-gcal squamous cell carcinoma in elderly patients. Methods: Forty-nine patients were randomly divided into two groups to receive cither radiotherapy only ( Group 1, 25 cases ) or weekly dose of Nedaplatin combined with radiotherapy ( Group 2, 24 cases). Patients in both groups received conventional radiotherapy with a total dose of 60 Gy to 66 Gy. In Group 2 30 mg/m2 of Nedaplatin was administered once a week for six successive weeks starting from the first day of radiotherapy Results: Among the 24 patients in Group 2, 10 patients achieved CR (41.7% ), 11 PR (45.8% ), and the reponse rate (' CR plus PR ) was 87.5%. On the other hand, in Group 1, 4 patients achieved CR (16.0%), 11 PR ( 44.0%), and the response rate (CR plus PR) was 60.0% (P < 0.05). The occurrence rate of G2/3 toxici-ty ofleukopenia in Group 2 was 54.2%, which was obviously higher than that in Group 1 ( P < 0.05 ). The occurrence rates of G2/3 tox-icity of radiation esophagitis between the two groups did not have statistical differences. Conclusion: Weekly dose of Nedaplatin combined with, radiotherapy can effectively treat esopbageai cancer in elderly patients.%目的:探讨放疗联合周剂量奈达铂治疗老年食管鳞癌患者的疗效及毒性.方法:选取49例老年食管癌患者,随机分为奈达铂每周化疗同步放疗(同步组)24例和单纯放射治疗(单放组)25例,两组放疗均采用常规分割,照射荆量60～66Gy.同步组奈达铂30mg/m2,每周1次,连续6周.结果:同步组完全缓解10例.部分缓解11例,有效率87.5%,单放组完全缓解4例,部分缓解11例,有效率60.0%.两组比较差异有统计学意义(P<0.05).同步组2～3度白细胞下降占54.2%,明显高于单放组的20.0%(P＜0.05).同步组3度血小板下降3例.单放组无3度血小板下降病例.两组2～3度放射性食管炎发生率差异无统计学意义(37.5%vs 32.0%).结论:奈达铂每周化疗同步放疗治疗老年食管癌近期疗效较好,骨髓抑制稍加重但可耐受.
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