HER-2阳性晚期乳腺癌患者预后差，以抗HER-2靶向治疗为基础的综合治疗显著延长了患者的生存期、改善了预后。目前多种抗HER-2靶向药物已应用于临床，抑制HER-2通路是HER-2阳性晚期乳腺癌患者一线治疗及一线治疗进展后的基础治疗。本文简要介绍HER-2阳性晚期乳腺癌治疗相关的关键临床研究、指南推荐及今后的研究方向，以指导临床实践。%Patients with HER-2-positive advanced breast cancer were associated with poor prognosis. Meanwhile, HER-2-targeted ther-apy has dramatically improved survival and prognosis among breast cancer patients. Over the years, multiple HER-2-targeting drugs stepped into clinical practice, and the targeted agents are now considered as the standard of care in the first-line setting and beyond. This review basically summarizes the importance of HER-2-targeted therapy, the significance of the clinical trial results, and the clinical practice guidelines for the management of patients with HER-2-positive advanced breast cancer.
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