锌-α2-糖蛋白在肿瘤恶病质脂肪代谢中的作用

摘要

Zinc-α2-glycoprotein (ZAG), a new adipokine, plays an important role in the development of cancer cachexia by decreasing lipid content in body via promoting lipid mobilization and utilization. The lipolytic effect of ZAG is achieved by increasing the activity of hormone sensitive lipase, activating β3 adrenergic receptors,and up-regulating cyclic adenosine monophosphate. In addition, ZAG increases adiponectin expression and decreases leptin expression in adipocytes and adipose tissue. The ZAG expression is regulated by glucocorticoid, peroxisome proliferator-activated receptor gamma agonist rosiglitazone, tumor necrosis factor-α and many other factors.ZAG can potentially be applied as a tumor marker, and may become a new target in the treatment of cancer cachexia.%锌-α2-糖蛋白(ZAG)是一种新型脂肪细胞因子,主要通过促进脂肪分解和利用来减少体内脂肪含量,在肿瘤恶病质的发生中发挥重要作用.ZAG促进脂肪分解的作用主要是通过增强激素敏感性脂酶活性、激活细胞膜上β3肾上腺素受体,进而上调细胞内环腺苷酸信号转导途径完成的.此外,ZAG能促进脂联素,抑制瘦素在脂肪细胞和脂肪组织中的表达.脂肪细胞中ZAG的表达受糖皮质激素、过氧化物酶体增殖物激活受体γ激动剂罗格列酮、肿瘤坏死因子-α等多种因素的调节.ZAG有作为肿瘤标志物的潜在价值,有望成为肿瘤恶病质治疗新的靶点.