Objective To use a measurement tool to assess systematic reviews (AMSTAR) to assess the methodological quality of published meta-analyses of intravenous fish oil interventions on clinical outcomes in postoperative or intensive care unit (ICU) patients supported with parenteral nutrition (PN).Methods PubMed,EMBASE,Cochrane Library,Web of Science,Chinese Biomedical Databases,China National Knowledge Infrastructure,Wanfang Database,and some other databases were searched to retrieve the eligible studies published from January 1996 to September 2013,and the relevant journals and the references of included studies were also retrieved manually.The studies were included if they were systematic reviews or meta-analyses that evaluated the effects of fish oil-enriched PN and standard PN for postoperative or ICU patients on clinical outcome.Two reviewers screened the literature according to the inclusion criteria and extracted the data.Then the AMSTAR was used to evaluate the quality of the included studies.Results A total of five relevant meta analyses were included.Based on AMSTAR,two studies were of high quality,one of moderate quality,and the other two were of low quality.Conclusions The methodological quality of these five published metaanalyses of intravenous fish oil interventions is uneven.Further large-scale and high-quality randomized controlled trials about the impact of intravenous fish oil on clinical outcomes and cost-effectiveness analysis for postoperative and ICU patients are needed.%目的 用评估系统评价测评工具(AMSTAR)对静脉鱼油对手术后及重症监护患者影响的系统评价进行质量评价.方法 计算机检索1996年1月至2013年9月美国生物医学文献检索系统(PubMed)、荷兰医学文摘检索系统(EMBASE)、Cochrane图书馆、Web of Science、中国生物医学文献数据库、中国知网、万方数据平台等数据库中研究静脉鱼油对患者临床结局影响的系统评价及Meta分析文献,同时手工检索临床营养相关期刊中论文,并回溯相关论文的参考文献.由两名研究者按照纳入标准独立筛选文献、提取资料后,采用AMSTAR量表评价纳入的系统评价质量.结果 共纳入5篇相关Meta分析.基于AMSTAR的质量评价结果显示,2篇Meta分析为高质量,1篇为中等质量,2篇为低质量.结论 已发表静脉鱼油对手术后及重症监护患者影响的Meta分析质量参差不齐,有部分为低质量Meta分析.今后需要更多样本量较大、质量较高的随机、对照、双盲研究报道来更新系统评价,观察静脉鱼油对手术后及重症监护患者的临床结局和成本-效果影响,以期得出更可靠的结论.
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