中医药对血管新生相关信号通路的影响

摘要

Angiogenesis is a common and important process of physiological and pathological.The process in-volves a lot of cells,cytokines and related signaling pathways.The development of many diseases are closely related to angiogenesis.Cytokines can affect angiogenesis by signaling pathways to mediate migration,proliferation,apoptosis of an-giogenesis-related cell.In recent years,new research about mechanism of angiogenesis shows that VEGF pathway,Notch pathway,PTEN /PI3K/AKTpathway,JAK/STAT pathway involved in regulating angiogenesis.Chinese medicine can be regulating angiogenesis by adjusting signal transduction pathways,and had made certain achievements in the treatment of angiogenesis-based diseases.%血管新生是机体常见的重要生理、病理过程，其过程涉及多种细胞、细胞因子及相关信号通路，多种疾病的发生发展均血管新生密切相关。细胞因子通过信号转导通路调节血管新生相关细胞的迁移、增殖、凋亡影响血管新生。近年来对血管新生机制的最新研究表明，VEGF 通路、Notch 通路、PTEN ／PI3K／AKT 通路、JAK／STAT 通路参与调节血管新生。中医药可通过调节信号转导通路调节血管新生，在治疗以血管新生为主要病变基础的疾病上取得了一定成绩。