脂蛋白（a）对冠心病的致病性研究

摘要

Objective To analyze the effect of lipoprotein (a)[LP(a)]in the pathogenic mechanism of cor-onary heart disease (CHD).Methods Four hundred and ninety-five individuals in this study were enrolled and di-vided into CHD group and non-CHD,and high level of LP(a)(>300 mg/L)group and low level of LP(a)(≤300 mg/L)group,the effect of LP(a)in the pathogenic mechanism of CHD was analyzed.Results Levels of LP(a)was 310.09 ±253.73 mg/L in CHD group,and 261.41 ±187.11 mg/L in Non-CHD group.Difference in levels of LP(a) between the two groups was significant (P <0.05).The incidence rate of CHD in the high level of LP(a)group was significantly higher than that in the low level of LP(a)group (P <0.05).Logostic regression analysis showed that LP (a),LDL-C,and ApoB were independent risk factors for CHD.Difference in levels of LP(a)between patients with statin treatment and patients without statin treatment was no significant (P >0.05).Conclusion Lp(a)is an inde-pendence risk factor for CHD,which may play important role in the pathogenic mechanism of CHD.%目的：分析血清脂蛋白（a）[Lp（a）]在冠心病发病中的作用。方法将入选的495例患者以Lp（a）水平300 mg／L 为切点，分为冠心病组（270例）、非冠心病组（225例），Lp（a）＞300 mg／L 组（174例）、Lp（a）≤300 mg／L 组（321例），分析 Lp（a）在冠心病发病中的作用。结果冠心病组血清 Lp（a）均值为（310．09±253．73）mg／L，非冠心病组为（261．41±187．11）mg／L，冠心病组明显高于非冠心病患者，差异有统计学意义（P ＜0．05）；Lp（a）＞300 mg／L 组冠心病患病率明显高于 Lp（a）≤300 mg／L 组，差异有统计学意义（P ＜0．05）；多因素 Logostic 回归分析显示，Lp（a）、LDL －C 和 ApoB 同为冠心病独立危险因素。服用他汀类药物者与未服用他汀类药物者 Lp（a）水平差异无统计学意义（P ＞0．05）。结论Lp（a）是冠心病的独立危险因素，在冠心病的发病中起着重要的作用。