Purpose To investigate the expressions of HER-2, pl6 and p53 protein in breast infiltrating ductal carcinoma and its clinical significance. Methods f49 patients were confirmed as breast infiltrating ductal cancer and were selected in our study which hospitalized from July in 2008 to December in 20f 0. Then pathologic and clinical data of patients were collected and the expressions of HER-2, p16 and p53 protein in breast infiltrating ductal cancer and normal tissues was detected. Results The positive rate of HER-2, pf6 and p53 protein in breast infiltrating ductal cancer was 23. 5% , 3f. 5% and 5f. 0% , repectively. Over-expression of HER-2 had a significant correlation with axillary lymph node metastasis and histological grade ( χ2 =5. 687, χ2 = 5. 924, both P < 0. 05 ). There was significant difference in the positive expression of p16 between the different age groups ( χ2 =4. 213 , P <0. 05 ). And there was significant difference in the positive expression of p53 between different histological grading ( χ2 =6. 378,P < 0. 05 ). There was a significant correlation between the expressions of HER-2, pl6 and disease-free survival time after operation. There was significant correlation between pl6 and p53 ( r = 0. 282 , P < 0. 05 ). Conclusions The expressions of HER-2, pl6 , and p53 protein are closely related with the development of breast invasive ductal cancer and thus they could be used as an important indicator for guiding treatment and predicting prognosis.%目的 探讨HER-2、p16、p53蛋白在乳腺浸润性导管癌中的表达情况及其临床意义.方法 收集2008年7月～2010年12月商丘市中心医院行手术治疗,术后证实为乳腺浸润性导管癌患者149例,检测HER-2、p16、p53蛋白在乳腺浸润性导管癌中以及正常组织中的表达情况.结果 乳腺浸润性导管癌HER-2过表达,阳性率为23.5%;p16、p53阳性率分别为31.5%和51.0%;HER-2过表达与腋窝淋巴结转移、组织学分级存在明显相关性(χ2=5.687、5.924,P均＜0.05);p16阳性表达在不同年龄之间存在统计学差异(χ2=4.213,P＜0.05),p53阳性表达在不同组织学分级之间存在统计学差异(χ2=6.378,P＜0.05);HER-2、p16表达与术后无瘤生存存在明显的相关性;p16与p53存在明显相关性(r=0.282,P＜0.05).结论 HER-2、p16、p53与乳腺浸润性导管癌的发生、发展密切相关,可作为临床指导治疗和评价患者预后的重要指标.
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