B细胞淋巴瘤中E2F1、BIRC5、PLK1蛋白表达及其临床意义

摘要

Purpose To investigate the expressions of E2F1, BIRC5 and PLK1 in B-cell lymphoma and their clinical significances. Methods 80 cases of B-cell lymphoma and 30 cases of reactive hyperplasia Lymph node were collected, the expressions of E2F1, BIRC5 and PLK1 were detected by immunohistochemistry. Results The positive rates of E2F1, BIRC5 and PLK1 expressions in B-cell lymphoma were higher than those in reactive hyperplasia lymph node( P < 0. 05 ). Their expressions were significantly correlated with the clinical stage, but not with age and occurrence site. The E2F1 and PLK1 expressions were significantly correlated with the degree of malignancy and histological type ( P < 0. 05 ), but the BIRC5 expression was not correlated with the degree of malignancy and histological type( P >0. 05 ). The E2F1 positive rate in male patients was higher than that in female patients( P < 0. 01 ), but the differences of BIRC5 and PLK1 expressions in different gender were not significant P >0. 05 ). And the expressions of E2F1, BIRC5 and PLK1 were positively correlated( P <0. 01 ). Conclusion The combined detection of E2F1, BIRC5 and PLK1 may be helpful to the diagnosis, treatment and prognosis of B-cell lymphoma.%目的 探讨E2F1、BIRC5、PLK1蛋白在B细胞淋巴瘤中的表达及其临床意义.方法 收集80例B细胞淋巴瘤及30例反应性增生淋巴组织,用免疫组化SP法检测两组中E2F1、BIRC5、PLK1的表达差异.结果 B细胞淋巴瘤中E2F1、BIRC5、PLK1蛋白表达均明显高于反应性增生组(P＜0.05),与临床分期密切相关(P＜0.01),与年龄、发生部位无关(P＞0.05).E2F1、PLK1蛋白表达与组织学亚型及恶性程度相关(P＜0.05),BIRC5表达与此二者无关(P＞0.05).E2F1在男性患者中的表达高于女性患者(P＜0.01),BIRC5、PLK1蛋白在不同性别组中的表达差异无显著性(P＞0.05).经Spearman等级相关分析发现E2F1、BIRC5、PLK1蛋白在B细胞淋巴瘤中的表达均呈正相关(P＜0.01).结论 联合检测E2F1、BIRC5、PLK1对B细胞淋巴瘤的诊断、治疗及预后判断具有一定的现实意义.