复杂天然产物合成人工生物系统的设计与构建

摘要

天然产物是人类疾病预防和治疗药物的最重要来源.合成生物学技术的蓬勃发展为天然产物的开发注入了全新的活力.文中重点介绍了如何利用合成生物技术进行复杂天然产物合成人工生物系统的设计与构建,包括与此相关的生物元件理性设计、生物元件挖掘、途径装配与集成,模块的组装与系统的适配等内容.%Natural products (NPs) are important drug pools for human disease prevention and treatment.The great advances in synthetic biology have greatly revolutionized the strategies of NPs development and production.This review entitled with design and construction of artificial biological systems for complex NPs biosynthesis,mainly introduced the progresses in artificial design of synthetic biological parts,naturally mining novel synthetic parts of NPs,the assembly & adaption of the artificial biological modules & systems.