雷公藤多苷对IgAN患者血清离子及β2-GPI／ox-LDL影响

摘要

目的：探讨雷公藤多苷对IgA肾病（IgA nephropathy，IgAN）患者血清离子及β2糖蛋白I（β2-glycoprotein，β2-GPI）／氧化低密度脂蛋白（ oxidized low density lipoprotein ，ox-LDL）的影响。方法收集丽水市人民医院肾内科2014年1月～2015年4月收治的原发性IgAN患者54例，随机分为对照组和实验组，每组27例，对照组患者常规给予盐酸贝那普利片10 mg，1次／天口服；给予双嘧达莫片50 mg，3次／天口服，实验组在对照组基础上给予雷公藤多苷片20 mg，3次／天口服。2组患者均治疗6个月。治疗结束后，对所有患者的血清Ca、P、β2-GPI／ox-LDL水平及肾功能相关指标进行检测。结果与对照组治疗后比较，实验组患者血清Ca水平较高，血清P水平较低（P＜0.05）；实验组患者的血清β2-GPI／ox-LDL水平较低（P＜0.05）；实验组患者的血清Scr、BUN水平较低（P＜0.05）。结论雷公藤多苷能够显著降低IgAN患者血清P、β2-GPI／ox-LDL、Scr及BUN水平，提高血清Ca水平，改善肾功能。%Objective To analyse effect of tripterygium glycosides on serum ion and β2-GPI/ox-LDL in patients with IgA nephropathy. Methods 54 patients who were diagnosed with primary IgA nephropathy in our hospital were collected.All patients were randomly divided into experimental group and control group, 27 cases in each group.Control group was given conventional Benazepri1 Hydrochloride Tablets 10 mg, 1 times per day orally;given Dipyridamole Tablets 50 mg, 3 times per day orally, patients in experimental group were given tripterygium glycosides 20 mg on the basis of control group treatment orally,3 times per day.All the patients were treated for 6 month.After the treatment, the serum levels of Ca,P,β2-GPI/ox-LDL and renal function related index were detected in all patients.Results Compared with control group post-treatment, the serum level of Ca was higher(P<0.05); and the serum level of P was lower in experimental group(P<0.05); the serum level of β2-GPI/ox-LDL was lower in experimental group(P<0.05);the serum levels of Scr and BUN were lower in experimental group(P<0.05).Conclusion The tripterygium glycosides can significantly reduce the serum levels of P,β2-GPI/ox-LDL,Scr and BUN,and increase serum Ca level in patients with IgA nephropathy, improve renal function.