百令胶囊联合西黄丸对Ⅲ期乳腺癌患者雌激素受体、基质金属蛋白酶、肿瘤标志物及雌激素的影响研究

摘要

Objective To investigate effect of Bailing Capsule combined with Xihuangwan in stage III breast cancer patients of ER, MMP-9, tumor markers and estrogen.Methods 76 Patients with stage III breast cancer were selected and divided into control group anf experiment group.Control group were treated by clinical routine method.Experiment group were treated on the base of the control group with Bailing Capsule combined with Xihuangwan.The ER, MMP-9, tumor markers, estrogen, survival time and quality of life were observed and compared.ResuIts Compared with control group, the survival period of the experiment group were longer(P<0.05),the quality of life score were higher(P<0.05),the ER, MMP-9, E2, E1 level and the serum levels of CA15-3, CA125 and CEA were lower(P<0.05).ConcIusion Bailing capsule combined with Xihuang Pill can effectively reduce stage III breast cancer tumor marker levels, decrease the ER, the expression of MMP-9 and estrogen level and prolong survival time, improve the quality of life, has the vital significance to the clinical therapy for stage III breast cancer.%目的：探讨百令胶囊联合西黄丸对Ⅲ期乳腺癌患者ER、MMP－9、肿瘤标志物及雌激素影响。方法选取已确诊为Ⅲ期乳腺癌的患者76例，采用随机数字表将患者随机分为实验组和对照组，对照组予临床常规方法治疗，实验组在与对照组相同的临床常规方法治疗基础上加用百令胶囊联合西黄丸治疗，疗程8周。观察2组患者ER、MMP－9、肿瘤标志物及雌激素及生存时间和生活质量。结果与对照组相比，实验组患者生存期均长于对照组（ P＜0．05）；实验组患者生活质量评分高于对照组（ P＜0．05）， ER、MMP－9、E2、E1水平低于对照组（P＜0．05），血清CA15－3、CA125、CEA表达水平低于对照组（P＜0．05）。结论百令胶囊联合西黄丸能有效降低Ⅲ期乳腺癌患者肿瘤标志物水平，降低ER、MMP－9表达及雌激素水平，延长生存时间、提高生活质量，对临床治疗Ⅲ期乳腺癌具有重要意义。