目的：探讨氨溴索静滴、布地奈德雾化联合头孢地嗪治疗小儿肺炎的临床疗效，并对患儿血清降钙素原（ procalcitonin， PCT），白介素－6（interleukin，IL－6）水平及相关免疫因子的影响。方法选取2013年5月～2015年10月于三亚市中医院收治的肺炎患儿95例，随机分为2组，其中对照组47例，实验组48例。2组均予退热、抗炎、加强营养等常规治疗，对照组在此基础上给予氨溴索静脉滴注，布地奈德雾化吸入，实验组在对照组基础上再给予头孢地嗪抗炎治疗，共治疗1周。观察2组患儿治疗前后血清PCT和IL－6水平、免疫因子水平变化，治疗有效率和不良反应情况。结果治疗后，实验组患儿血清PCT、IL－6水平均显著低于对照组， CD4＋、CD4＋／CD8＋水平均显著高于对照组，CD8＋水平低于对照组，2组比较差异均有统计学意义（ P＜0．05）；实验组治疗有效率为93．75％，明显高于对照组的80．85％（P＜0．05）；2组不良反应比较差异无统计学意义。结论氨溴索静滴、布地奈德雾化联合头孢地嗪能有效降低小儿肺炎患儿血清PCT、IL－6水平，有效改善临床症状，具有较好的临床疗效。%Objective To investigate the clinical efficacy of ambroxol intravenous and budesonide atomizing inhalation combined with cefodizime on infantile pneumonia and its effects of serum PCT, IL -6 levels and related immune factors.Methods 95 children with pneumonia from May 2013 to October 2015 in Sanya Hospital of Traditional Chinese Medicine were collected and randomly divided into control group(n=47) and experiment group (n=48), two groups were treated by clinical routine treatment, such as antipyretic, anti-inflammatory, strengthen nutrition in children, and control group were added with ambroxol, iv, qd; experiment group were added cefodizime on the basis of control group, the course was one week.Clinical efficacy,serum PCT, IL -6 levels, immune factors and adverse reactions were observed and compared.Results The serum PCT and IL -6 levels of experiment group were lower than control group post-treatment, and CD4 +, CD4 +/CD8 +levels were higher than control group, CD8 +level was lower than control group, the differences were all significant (P<0.05).The effective rate of experiment group was 93.75%, higher than 80.85% of control group(P<0.05).Incidence of adverse reactions between two groups had no statistical difference.Conclusion Ambroxol intravenous and budesonide atomizing inhalation combine with cefodizime in treatment of infantile pneumonia has better clinical efficacy, could effectively reduce the serum PCT and IL-6 levels, effectively improve the clinical symptoms.
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