Liposomes are a major concern in the treatment of tumor drug delivery systems,such as the delivery of antimicrobial peptides, proteins, drugs and so on. PEG-modified liposomes can prolong the circulating time of liposomes in vivo, but it also has some drawbacks,for example,the weaker ability of PEG-modified liposomes to reach the tumor site will limit the ability of liposomes to enter the cells; Hinder pH-sensitive liposome cells within the "escape "; Repeated injection of PEG ylated liposomes in the same animal can induce accelerated blood clearance. In order to solve these problems, it has been studied to use peptides to modify liposomes in order to enhance targeting of tumor cells, peptides and PEG co-modified liposomes, and to make use of drug delivery systems promising. By summarizing the progress and innovation of the existing concept of liposomal drug delivery, we will focus on the advantages and disadvantages of polypeptide-mediated liposome targeting, and introduce the functions of emerging peptides and PEG co-modified liposomes .%脂质体作为治疗肿瘤药物的载送系统而备受关注,例如用于递送抗菌肽、蛋白质、药物等.PEG修饰的脂质体可以延长脂质体在体内的循环时间,但是其也有一定的缺点,例如PEG修饰的脂质体到达肿瘤部位后,PEG具有较弱的穿透能力,它会限制脂质体进入细胞进一步发挥作用;妨碍pH敏感性脂质体在细胞内的"逃逸";同一动物体内重复注射PEG化脂质体会诱发血液清除加速现象等.为了解决这些问题,人们开始研究利用多肽来修饰脂质体,以便增强对肿瘤细胞的靶向作用,多肽和PEG共修饰的脂质体的提出,使药物递送系统的使用有了希望.通过概述现有的脂质体药物传递概念的进展和创新,本文将重点介绍多肽介导的脂质体活性靶向的优点及缺点,介绍新兴的多肽和PEG共修饰脂质体的功能.
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