4例替加环素致肝功能衰竭的临床分析

摘要

目的 提高临床对替加环素不良反应的认识.方法 介绍在本院发生的4例经替加环素治疗后发生急性或亚急性肝功能衰竭病例,并对其进行分析,包括年龄、基础病、合并用药、肝功能衰竭发生时间、替加环素的用量和疗程.结果 4例患者年龄49~77岁,平均年龄(67.5±12.79)岁,肝衰竭发生时间6~20 d,平均(11.75±6.24)d,疗程9~23 d,平均(9.75±6.63)d,替加环素总剂量900~3650 mg,平均(1812.5±1243.23)mg.4例患者均有多种基础病,合用多种药物,并且都有机械通气.结论 应用替加环素时,应高度警惕其不良反应.%Objective To pay more attention to the adverse drug reactions caused by tigecycline. Methods Four cases in our hospital which happened acute or subacute liver failure after the uses of tigecycline were analyzed, including age, basic disease, drug combination,the time when liver function failure happen ,dosage of tigecycline and the course of treatment. Results The aged of four patients was 49-77 years old, the average age (67.5±12.79)years; the time when liver failure happened from 6 d to 20 d, the average(11.75±6.24) d; the course of treatment was 9 d to 23 d, the average(9.75±6.63) d; the total dose of tigecycline was 900 mg to 3650 mg, the average (1812.5±1243.23) mg.The four patients have many basic diseases, combined with many drugs, all of them have mechanical ventilation. Conclusion More attention should be paid to adverse events caused by tigecycline.