兰索拉唑联合氟哌噻吨美利曲辛治疗功能性消化不良患者的疗效及不良反应

摘要

目的 对功能性消化不良患者经兰索拉唑联合氟哌噻吨美利曲辛治疗后的疗效及不良反应进行分析.方法 选取2013年12月～2015年12月在浙江省舟山市中医院治疗的90 例功能性消化不良的患者,采用随机数字表法分为对照组和观察组,每组45例.对照组采取口服兰索拉唑肠溶胶囊,观察组采取口服兰索拉唑和氟哌噻吨美利曲辛,疗程共4 周,比较2 组患者的疗效和不良发应发生情况.结果 治疗4 周后观察组患者的四项不适症状GSRS 评分餐后饱胀不适分、早饱感分、上腹痛分、上腹灼烧感分均低于对照组的对应分,同时差异具有统计学意义( P< 0.05);观察组患者治疗4周后的总有效率(86.7％)明显高于对照组(66.7％),且差异具有统计学意义( P< 0.05);且2组患者在用药过程中出现的不良反应症状均较轻微,未给予特殊处置,基本于数日后得以缓解.结论 兰索拉唑联合氟哌噻吨美利曲辛可有效消除或减轻功能性消化不良患者的临床不适症状,且无严重不良反应,临床应用安全性高.%Objective To analyze the curative effect and adverse reaction of lansoprazole combined with droperidol thiadiazole melitracen treatment in patients with functional dyspepsia.Methods From December 2013 to December 2015 in our hospital and accepted treatment of 90 patients with functional digestive adverse as the research object,according to the random number table were divided into the control group and the observation group,45 cases in each group.The control group by oral administration of lansoprazole enteric coated capsules,the observation group taking oral lansoprazole and droperidol thiadiazole melitracen,course lasted for 4 weeks,efficacy and adverse occurrence was compared between two groups of patients.Results After 4 weeks of treatment,the observation group with symptoms score GSRS(postprandial fullness discomfort,early satiety,abdominal pain,epigastric burning sensation were lower than the control group with postprandial fullness discomfort early satiety,abdominal pain,epigastric burning sensation,and the difference was statistically significant(P<0.05); the patients in the observation group after 4 weeks of treatment,the total effective rate(86.7％)was higher than the control group(66.7％)significantly,and difference was statistically significant(P<0.05); symptoms of adverse reactions of two groups of patients in the process of drug use were mild and did not give special treatment,in a few days after the basic relief.Conclusion Lansoprazole combined with fluorine Pai Sai tons of Murray Song Xin can effectively eliminate or reduce the symptoms of functional dyspepsia patients clinical and no serious adverse reactions,it is safe in clinical application.