兰索拉唑、莫沙必利联合氟哌噻吨美利曲辛对质子泵抑制剂治疗效果不佳功能性消化不良患者的效果

摘要

目的：探讨兰索拉唑、莫沙必利联合氟哌噻吨美利曲辛对质子泵抑制剂(PPI)治疗效果不佳功能性消化不良(FD)患者的疗效。方法：收治 PPI 治疗效果不佳的 FD 患者96例，随机分为对照组和观察组，对照组予以兰索拉唑、莫沙必利治疗，观察组在对照组基础上予以氟哌噻吨美利曲辛治疗，观察两组临床疗效及不良用药反应。结果：观察组治疗有效率、治疗后SAS评分、SDS评分均显著高于对照组(P＜0.05)。结论：PPI治疗效果不佳FD患者可辅以氟哌噻吨美利曲辛，消除负面情绪，提高临床疗效。%Objective:To investigate the efficacy of lansoprazole,mosapride combined with flupentixol and melitracen on patients with functional dyspepsia who has unsatisfactory curative effect on proton pump inhibitors.Methods:96 patients with FD who has unsatisfactory curative effect on PPI therapy were selected.They were randomly divided into the control group and the observation group.Patients in the control group were received lansoprazole and mosapride treatment,while the observation group were added flupentixol and melitracen treatment based on the treatment taken by the control group,then we observed the clinical curative effect and adverse drug reaction in the two groups.Results:The treatment efficiency,SAS score and SDS score in the observation group were significantly higher than those in the control group(P<0.05).Conclusion:Patients with FD who has unsatisfactory curative effect on PPI therapy in combined with flupentixol and melitracen can eliminate the negative emotions,and also improve the clinical efficacy.