慷舒灵凝胶对Ⅱ度烧伤患者的疗效及对血清炎症因子的影响

摘要

Objective To investigate the effect of Kang Shueling gel on the degree of inflammation in the patients with Ⅱ degree burns. Methods 86 patients with Ⅱ degree burns from July 2014 to July 2016 in our hospital were divided into the control group and the experimental group by lottery method with 43 cases in each group. The control group was treated with silver sulfadiazine, the experimental group was treated with Kang Shuling gel, the two groups of clinical curative efficacy, inflammatory factors, visual analogue scale (VAS), wound healing rate and wound healing time, wound infection rate and adverse drug reactions were compared. Results After treatment, the total effective rate of the experimental group was 95.34% higher than that of the control group 72.09%, the difference was statistically significant (P<0.05). The tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6) levels of the experimental group was lower than the control group, the difference was statistically significant (P<0.05). The VAS of the experimental group was lower than the control group, the difference was statistically significant (P<0.05).The wound healing rate of the experimental group was higher than that of the control group on the seventh day and the fourteenth day, and the wound healing time was better than that of the control group, the difference was statistically significant (P<0.05). The wound infection rate of the experimental group was lower than that of the control group (P<0.05). There was no significant difference in adverse drug reactions between the two groups. Conclusion The curative effect of Kang Shuling gel on the treatment of Ⅱ degree burns patients worthy of affirmation, could reduce serum inflammatory factors level.%目的 探讨慷舒灵凝胶对Ⅱ度烧伤患者的疗效及对血清炎症因子的影响.方法 选择2014年7月~2016年7月于山东省烟台市解放军第107医院就诊的86例Ⅱ度烧伤患者,参照抽签法将患者分为对照组与实验组,每组各43例.对照组采用磺胺嘧啶银治疗,实验组采用慷舒灵凝胶治疗,比较2组临床疗效,炎症因子,视觉模拟评分(visual analogue scale,VAS),创面愈合率及创面愈合时间,创面感染率和药物不良反应.结果 治疗后,实验组总有效率为95.34%高于对照组的72.09%,差异有统计学意义(P<0.05).实验组肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)水平低于对照组,差异有统计学意义(P<0.05).实验组VAS评分低于对照组,差异有统计学意义(P<0.05).实验组第7天、第14天创面愈合率均高于对照组,且创面愈合时间优于对照组,差异有统计学意义(P<0.05).实验组创面感染率低于对照组,差异有统计学意义(P<0.05).2组药物不良反应比较差异无统计学意义.结论慷舒灵凝胶对Ⅱ度烧伤患者的疗效值得肯定,能够降低血清炎症因子水平.