脑电反馈对共患注意缺陷多动障碍和学习障碍儿童血清β-内啡肽、脑源性神经营养因子影响

摘要

Objective To investigate the effect of EEG biofeedback treatment on serum β-EP and BDNF of children with comorbidity of attention deficit hyperactivity disorder(ADHD)and learning disorder.Methods Forty-eight children(ages 6～12)with comorbidity of ADHD and learning disorder diagnosed according to ICD-10 received 40 sessions of EEG biofeedback treatment.Feedback was contigent on enhancing 16～20Hz beta activity and suppressing 4～8 Hz theta activity.Serum levels of β-endorphin and BDNF were measured by enzyme linked immunosorbent assay.Results After treatment significante decreases were observed in the EEG ratio of the theta/beta and theta/SMR(P＜0.01).The mean concentration of serum β-EP increased significantly [(180.29±32.38)pg/ml Vs(191.01±22.85)pg/ml,t=3.86,P＜0.01].The mean concentration of serum BDNF had no significant change[(6.12 ±6.44)ng/ml Vs(4.40±3.68)ng/ml,t=1.71,P＞0.05].Conclusion It seems that highly β-EP levels play a role in the EEG biofeedback treatment pathogenesis of comorbidity of ADHD and learning disorder%目的 探讨脑电生物反馈治疗对共患注意缺陷多动障碍(ADHD)和学习障碍患儿血清beta-内啡肽(β-EP)、脑源性神经营养因子(BDNF)影响.方法 应用Sprit-8脑电生物反馈治疗仪,对48例(6～12岁)共患ADHD和学习障碍儿童进行40次增强16～20 Hz β波,抑制4～8 Hz θ波脑电反馈治疗,采用脑电反馈仪检测患儿脑电波θ/β、θ/SMR功率比值的变化,采用酶联夹心免疫吸附测定法检测血清浓度.结果 脑电反馈治疗后患儿θ/β、θ/SMR值较前明显下降(P<0.01),血清β-EP浓度[(191.01±22.85)pg/ml]较前[(180.29 4-32.38)pg/ml]升高(t=3.86,P<0.01),血清BDNF浓度前后分别为(6.12±6.44)ng/ml,(4.40±3.68)ng/ml,差异无显著性(t=1.71,P>0.05).结论 β-EP可能在脑电生物反馈治疗共患ADHD和学习障碍机制中扮演蕈要角色.