以二唾液酸神经节苷脂为靶点对神经母细胞瘤行免疫治疗的研究进展

摘要

Neuroblastoma(NB),the common extracranial solid tumor of childhood,is thought to derive from neural crest cells.In disialoganglioside (GD)2 is highly expressed on NB,whereas GD2 expression is weak and restricted to the central nervous system,peripheral pain fibers and skin melanocytes.Therefore,GD2 is an ideal antigen target for immunotherapy of NB.The research progress on GD2 as target for immunotherapy of NB was reviewed.%神经母细胞瘤(NB)是起源于神经嵴细胞的儿童常见颅外实体瘤.二唾液酸神经节苷脂(GD)类的GD2在NB中高度表达,但在正常组织中表达水平低且仅限于中枢神经系统、周围痛觉纤维以及皮肤黑色素细胞.因此GD2是NB免疫治疗的理想靶点.现就以GD2为靶点的NB免疫治疗的研究进展进行综述.