Incorporation of ganglioside gm1 in multilamellar liposomes for application to immunotherapy

摘要

The natural targeting of liposomes in vivo is the immunological system, where the liposomes are recognized as foreign particles and uptaken by the reticuloendothelial system (RES). this natural targeting is responsible for important applications of liposomes, such as immunoadjuvant in vaccines and activators of macrophages. Both applications are related to modulation of an immune response by an antigen associated on liposome vesicles.