能量感应网络 AMPK／SIRT1／PGC-lα对骨骼肌纤维类型转化调节

摘要

AMP-activated protein kinase ( AMPK ) , peroxisome proliferator-activated receptor γco-activator 1α( PGC-1α) and silent information regulator 1 ( SIRT1) act as an orchestrated network to regulate the signal of cellular energy output, that is called energy sensing, to modulate energy metabolism, mitochondria and muscle fiber transformation of the whole body.This review extracted the new advances and summarized the critical roles of the AMPK/PGC-1α/SIRT1 energy network in regulating muscle fiber transformation, so as to provide references for livestock production and human nutrition.%腺苷酸活化蛋白激酶（ AMPK）、沉默信息调节因子1（ SIRT1）和过氧化物酶体增殖激活受体γ辅助激活因子α（ PGC-1α）构成一个调节细胞能量输出的信号网络，即能量感应网络，共同调节机体能量代谢、线粒体功能以及肌纤维类型的转化。本文拟综合国内外最新研究报道，总结AMPK／SIRT1／PGC-lα能量感应网络在肌纤维类型转化过程中所发挥的重要作用，为畜牧生产以及人的营养研究提供参考。