The present invention relates to a method for regulating the differentiation of adipocytes from embryonic stem cells by controlling the expression of SIRT1 (silent mating type information regulation 2 homolog: sirtuin 1). The present invention relates to a method for regulating the differentiation of adipocytes from embryonic stem cells As the control method can control the inhibition or promotion of differentiation of adipocytes according to the treatment period of SIRT1 expression inhibitor, it can be used not only as a model for obesity such as childhood obesity according to the inhibition timing of SIRT1 expression in the embryo, And thus can be used as an inhibitor or therapeutic agent for obesity, obesity, diabetes mellitus, and metabolic diseases.
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