中性粒细胞参与大疱性类天疱疮发生的相关机制

摘要

大疱性类天疱疮(bullous pemphigoid,BP)是由自身抗体攻击基底膜带半桥粒蛋白BP230和BP180而导致的以真表皮分离、水疱形成为特点的一种获得性自身免疫性疱病.在IgG被动转移BP鼠模型中,自身抗体攻击基底膜带后可激活补体,肥大细胞脱颗粒,中性粒细胞、嗜酸性粒细胞等聚集,释放蛋白酶损伤基底膜带,导致水疱形成.其中,中性粒细胞的有无直接决定了水疱能否产生,本文对中性粒细胞参与BP发生的具体过程进行综述,以深入了解BP的发生机制,为疾病的干预提供新视角%Bullous pemphigoid (BP) is an autoimmune skin disease characterized by the binding of autoantibodies to components of the hemidesmosome structure (BP230 and BP180),resulting in an inflammatory response and subepidermal blister formation.Binding of pathogenic autoantibodies activate complement cascade,neutrophils,mast cells,macrophages and other inflammatory cells.In this study,we summarized the role of neutrophils in the immunopathogenesis of BP mouse model,and will throw light on the new direction for disease intervention.