Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

Nishide Masayuki; Nojima Satoshi; Ito Daisuke; Takamatsu Hyota; Koyama Shohei; Kang Sujin; Kimura Tetsuya; Morimoto Keiko; Hosokawa Takashi; Hayama Yoshitomo; Kinehara Yuhei; Kato Yasuhiro; Nakatani Takeshi; Nakanishi Yoshimitsu; Tsuda Takeshi; Park Jeong Hoon; Hirano Toru; Shima Yoshihito; Narazaki Masashi; Morii Eiichi; Kumanogoh Atsushi

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Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

机译：Semaphorin 4d抑制中性粒细胞激活，并参与中性粒细胞介导的自身免疫血管炎的发病机制

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Objectives Inappropriate activation of neutrophils plays a pathological role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The aim of this study was to investigate the functions of semaphorin 4D (SEMA4D) in regulation of neutrophil activation, and its involvement in AAV pathogenesis.

机译：目的在嗜中性粒细胞的不当活动中发挥着病理作用在抗替诺罗氏醇细胞质抗体（ANCA） - 分配的血管炎（AAV）中。本研究的目的是探讨Semaphorin 4d（Sema4d）在中性粒细胞激活调节中的功能，及其参与AAV发病机制。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2017年第8期|共9页
作者
Nishide Masayuki; Nojima Satoshi; Ito Daisuke; Takamatsu Hyota; Koyama Shohei; Kang Sujin; Kimura Tetsuya; Morimoto Keiko; Hosokawa Takashi; Hayama Yoshitomo; Kinehara Yuhei; Kato Yasuhiro; Nakatani Takeshi; Nakanishi Yoshimitsu; Tsuda Takeshi; Park Jeong Hoon; Hirano Toru; Shima Yoshihito; Narazaki Masashi; Morii Eiichi; Kumanogoh Atsushi;
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Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

World Premier Int Immunol Frontier Res Ctr Lab Immunopathol Suita Osaka Japan;

World Premier Int Immunol Frontier Res Ctr Lab Immunopathol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

World Premier Int Immunol Frontier Res Ctr Lab Immunopathol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

World Premier Int Immunol Frontier Res Ctr Lab Immunopathol Suita Osaka Japan;

World Premier Int Immunol Frontier Res Ctr Lab Immunopathol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Pathol Suita Osaka Japan;

Osaka Univ Grad Sch Med Dept Resp Med &

Clin Immunol Suita Osaka Japan;

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正文语种 eng
中图分类免疫性疾病;
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专利

1. Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis [J] . Nishide Masayuki, Nojima Satoshi, Ito Daisuke, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2017,第8期

机译：Semaphorin 4d抑制中性粒细胞激活，并参与中性粒细胞介导的自身免疫血管炎的发病机制
2. A novel adenosine analog, AMP579, inhibits neutrophil activation, adherence and neutrophil-mediated injury to coronary vascular endothelium. [J] . Nakamura M, Zhao ZQ, Clark KL, European Journal of Pharmacology: An International Journal . 2000,第1期

机译：新型腺苷类似物AMP579抑制嗜中性粒细胞活化，粘附和中性粒细胞介导的冠状血管内皮损伤。
3. Macrophage scavenger receptor 1 contributes to pathogenesis of fulminant hepatitis via neutrophil-mediated complement activation [J] . Tang Yuan, Li Huifang, Li Junru, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2018,第4期

机译：巨噬细胞清除剂受体1通过中性粒细胞介导的补体激活有助于膨胀肝炎的发病机制
4. Autoimmune consequences of histone deimination during neutrophil activation [D] . Dwivedi, Nishant 2011

机译：中性粒细胞活化过程中组蛋白脱氨的自身免疫后果
5. Extended report: Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis [O] . Masayuki Nishide, Satoshi Nojima, Daisuke Ito, -1

机译：扩展的报告：Semaphorin 4D抑制中性粒细胞活化并参与中性粒细胞介导的自身免疫性血管炎的发病机理
6. Inhibition of neutrophil-mediated production of reactive oxygen species (ROS) by endothelial cells is not impaired in anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis patients [O] . Al Laham, F., Kaelsch, A. -I., Heinrich, L., 2010

机译：在抗中性粒细胞胞质自身抗体（ANCA）相关血管炎患者中，内皮细胞对中性粒细胞介导的活性氧（ROS）产生的抑制作用不会受到损害

Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

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