目的 探讨ALT正常的慢性HBV感染者的肝组织病理特征,并分析性别,年龄、ALT、血清HBV DNA及HBeAg对肝组织病理改变的影响.方法 选取123例肝功能正常的慢性HBV感染者进行肝组织病理检查,根据性别、年龄、ALT、血清HBV DNA及HBe Ag进行分组,并分别比较各组患者肝组织炎症分级和纤维化分期之间的差异.统计学处理采用方差分析.结果 HBV携带者性别、HBV DNA水平对肝脏损害程度的影响差异无统计学意义(P＞0.05)；随年龄增加、ALT水平升高,肝组织炎症及纤维化呈加重的趋势(P＜0.01)；血清HBeAg阳性与阴性对纤维化程度的影响差异有统计学意义(P＜0.05).结论 对于年龄＞40岁、ALT水平接近正常值上限的HBV携带者,应尽早进行肝脏活组织检查,根据不同病理结果决定是否进行抗病毒治疗.%Objective To study the liver pathological character of chronic HBV cariers with normal ALT level and its correlation between gender, age, ALT,serum HBV DNA and serum HBeAg, Methods The clinical and pathological data of 123 chronic HBsAg carriers (ASC) with normal liver function were collected. Groups were divided based on gender,age, ALT, serum HBV DNA and serum HBeAg and the differences on liver inflammation grades and fibrosis stages were respectively compared among different groups. Results There was no significant defference between degree of damage in liver tissue and gender, HBV DNA. Hepatic inflammation and fiber proliferation of hepatic tissue were significantly increased with increasing age and level of ALT. The levels of liver fibrosis in HBeAg negative groups were significantly more severe than HBeAg positive group. Conclusion Liver biopsies should be conducted for those over 40 years old and ALT level close to the normal upper limit. Antiviral treatment should be given to the appropriate patients based on the pathology.
展开▼
