目的 观察贝前列素对老年糖尿病肾病患者的肾功能及凝血功能的影响.方法 选择40例老年糖尿病肾病患者,采用随机数字表分为治疗组和对照组,每组20例.两组均给予控制血糖、血压、血脂等常规治疗及对症处理,治疗组在基础治疗上给予贝前列素钠联合复方α-酮酸片治疗;对照组在基础治疗上给予复方а-酮酸片治疗.两组均30 d为1个疗程,连续治疗2个疗程后,观察患者的肾功能指标(血尿素氮、血肌酐)、24 d尿蛋白、凝血指标(纤维蛋白原、D-二聚体)的变化及不良反应并比较.结果 治疗前两组患者的血尿素氮、血肌酐、24 h尿蛋白定量、血浆D-二聚体及FIB水平比较,差异均无统计学意义(P＞0.05);而治疗后两组患者上述各指标比较,差异均有统计学意义(P＜0.05).结论 老年糖尿病肾病患者加用贝前列素钠治疗可降低血浆纤维蛋白原、血浆D-二聚体、血肌酐、血尿素氮及24 h尿蛋白水平,改善患者的内皮功能和纤溶活性,加快肾脏清除毒素的能力,延缓糖尿病肾病进程.%Objective To investigate the impact of beraprost sodium on renal function and blood coagulation of elderly patients with diabetic nephropathy ( DN ). Methods Forty elderly DP patients were divided randomly into Gl ( therapeutic group ) and G2 ( control group ), 20 in each. Both groups were given a basic treatment, and based on it, G2 treated with compounda - keto acid tablets, Gl combined with additional beraprost sodium. The therapeutic results and side effects were e-valuated. Results Clinical symptoms were improved significantly and levels of blood urea nitrogen ( BUN ), serum creatinine ( Scr), blood FIB, urinary protein decreased significantly in Gl after treatment ( P < 0. 05 ). Conclusion In aged DP patients, beraprost sodium can lower the levels of BUN, Scr, D-dimer, FIB, 24 h urine protein, and improve endothelial function and fibrinolytic activity, accelerate the ability of kidneys removing toxins, slow down the process of DP.
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