炎症性肠病患者生存质量问卷调查研究

摘要

Objective To assess the health - related quality of life in patients with inflammatory bowel disease ( IBD ) by inflammatory bowel disease questionaire ( IBDQ ). Methods Totally 172 patients from the in - hospital and clinical services in Peking Union Medical College Hospital were enrolled in this study. The severity of IBD was evaluated by Truelove criteria for ulcerative colitis ( UC ) and Harvey - Bradshaw criteria for Crohn's disease ( CD ). Patients were divided into three groups: mild group ( or remission group ), moderate group, and severe group. IBDQ was completed by interview. Nutritional status was evaluated by nutritional risk screening ( NRS2002 ). Results Totally 172 patients ( UC, n = 102; CD, n = 70; male, n = 95 , female, n =77 ) completed the IBDQ. The total score of IBDQ as well as all 4 domains negatively correlated with disease activity ( P < 0. 001 ). The IBDQ was able to discriminate between active and inactive CD ( P < 0. 001 ), but it could not discriminate between moderate active and severe active CD ( P =0. 366 ). There were no significant correlations between the total score of IBDQ and patient's diagnosis ( UC or CD ), age, sex, medical insurance, or nutritional risk (P>0. 05). Conclusion IBDQ is negatively correlated with the severity of IBD and therefore can be used to assess the health - related quality of life of patients with IBD.%目的 应用炎症性肠病生存质量问卷(IBDQ)评价炎症性肠病(IBD)患者的生存质量.方法 选择172例门诊及住院IBD患者进入本研究,IBD病情评估:溃疡性结肠炎(UC)参考True-Love标准分为轻型、中型、重型.克罗恩病(CD)依据Harvey和Bradshaw标准分组:积分＜4分为缓解期,4～8分为中度活动期,≥9分为重度活动期.调查以面谈方式进行.营养风险评估采用NRS2002方法.结果 172例患者中UC 102例,CD 70例;男95例,女77例.患者IBDQ总分及其4个维度评分与病情严重程度呈负相关(P＜0.001).CD组缓解期和活动期的IBDQ总分间差异有统计学意义(P＜0.001),但中度活动组和重度活动组的IBDQ总分间差异无统计学意义(P=0.366).患者疾病诊断(UC或CD)、年龄、性别、医疗费用以及营养风险等因素与IBDQ评分无显著相关.结论 IBDQ与IBD患者病情严重程度呈负相关,可有效评价患者的生存质量.