目的:对比奈达铂(NDP)联合氟尿嘧啶(5-FU)与顺铂(DDP)联合氟尿嘧啶治疗老年晚期食管癌的效果和不良反应。方法:收治老年晚期食管癌患者46例,随机分为NDP+5-FU治疗组(A组,24例)和DDP+5-FU对照组(B组,22例),比较两组患者的疗效和不良反应。结果:A组总有效率27.53%,B组总有效率22.73%(P<0.05)。A组主要不良反应为骨髓抑制,B组主要不良反应为消化道反应。结论:奈达铂治疗老年晚期食管癌患者的效果显著,不良反应小。%Objective:To explore the curative effect and adverse reactions of nedaplatin combined with 5-fluorouracil and cisplatin combined with 5-fluorouracil in the treatment of elderly patients with advanced esophageal cancer.Methods:46 elderly patients with advanced esophageal cancer were selected,they were randomly divided into NDP+5-FU treatment group(A group,24 cases) and DDP+5-FU control group(B group,22 cases),we compared the efficacy and adverse reactions of the two groups.Results:The total effective rate in the A group was 27.53%,and the total effective rate in the B group was 22.73%(P<0.05).In the A group, the main adverse reactions were bone marrow suppression,in the B group,the main adverse reactions were gastrointestinal reactions.Conclusion:Effect of nedaplatin in the treatment of elderly patients with advanced esophageal carcinoma was significant, adverse reaction was small.
展开▼