免疫预防乙型肝炎病毒母婴传播及乙肝疫苗接种的效果分析

摘要

Objective:To explore the clinical effect of immune prevention of perinatal transmission of hepatitis B virus and hepatitis B vaccination.Methods:220 cases of HBsAg positive pregnant women and their babies were selected.We investigated the use of HBIG of pregnant women and infants immunization way,and detected the hepatitis B serum marker of infants.Results:HBsAg positive rate of 4.9% in infants of HBIG injection of pregnant women,the positive rate of HBsAg was 3.4% of the infants without HBIG injection,the differences between the groups was not significant(P>0.05).HBsAg positive rate was 5.9% of the infants group with only hepatitis B vaccination,and the positive rate was 2.7% of the infants group immunized with HBIG combined with hepatitis B vaccine.There was statistically significant of two groups(P<0.05).Conclusion:For HBsAg positive pregnant women and their babies,in order to prevent mother to child transmission of hepatitis B virus,HBIG immunization of pregnant women can not reduce mother to child transmission of HBV,and we should conduct hepatitis B vaccination and injection of HBIG on the baby,in order to reduce infant HBV infection rate.%目的：探究免疫预防乙型肝炎病毒母婴传播及乙肝疫苗接种的临床效果。方法：收治HBsAg阳性孕妇及其婴儿220例，调查孕妇 HBIG 使用情况及婴儿免疫方式，检测婴儿乙肝血清标志物。结果：孕妇注射 HBIG 的婴儿HBsAg阳性率4.9%；未注射HBIG的婴儿组HBsAg阳性率3.4%，组间差异不具有统计学意义(P＞0.05)；单纯进行乙肝疫苗接种的婴儿组HBsAg阳性率5.9%，HBIG与乙肝疫苗联合免疫的婴儿组阳性率2.7%，两组比较差异有统计学意义(P＜0.05)。结论：对于HBsAg阳性孕妇及其婴儿，为了阻断乙肝病毒的母婴传播，对孕妇进行HBIG免疫预防无法降低HBV的母婴传播，而应当对其婴儿进行乙肝疫苗接种和注射HBIG，从而降低婴儿的HBV感染率。