不同剂量右美托咪定对老年患者全髋关节置换术后谵妄发生率的影响对比

摘要

目的：探讨不同剂量右美托咪定对老年患者全髋关节置换术后炎性指标、不良反应及苏醒时间的影响。方法：收治全髋关节置换术老年患者90例，分为对照组(生理盐水)、低剂量右美托咪定组(低剂量组)与高剂量右美托咪定组(高剂量组)。结果：术后低剂量组与高剂量组CRP水平均明显低于对照组(P＜0.05)；高剂量组心动过缓、低血压等不良反应发生率均明显高于对照组与低剂量组(P＜0.05)，而拔管时间及苏醒时间均明显长于对照组与低剂量组(P＜0.05)。结论：老年全髋关节置换术患者麻醉诱导前给予低剂量右美托咪定，具有抑制应激反应、炎性反应等作用，且不良反应发生率降低。%Objective:To explore the different doses of dexmedetomidine on inflammatory markers,adverse reactions and the recovery time after total hip joint replacement in elderly patients.Methods:90 elderly patients with total hip replacement were selected.They were divided into the control group(saline),the low dose dexmedetomidine group(the low dose group)and the high dose dexmedetomidine group(the high dose group).Results:After operation,the levels of CRP in the low dose group and the high dose group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions such as tachycardia,hypotension and so on in the high dose group was significantly higher than that in the control group and the low dose group(P<0.05).The extubation time and recovery time were significantly longer than those of the control group and the low dose group(P<0.05).Conclusion:The low doses of dexmedetomidine applied in elderly patients after total hip replacement before anesthesia induction,which has the function of inhibiting stress reaction and inflammation reaction,and the incidence of adverse reaction is reduced.