两种不同淋巴结示踪剂在腹腔镜下宫颈癌根治术中的应用对比

摘要

Objective To explore the application of methylene blue and carbon nanoparticles suspension injection as lymphatic tracers in laparoscopic radical resection of cervical cancer.Methods Fifty patients diagnosed as cervical cancer from 2015 to 2016 were enrolled in this study,and were randomly divided into methylene blue group and carbon nanoparticles suspension injection group with 25 patients in each group.The detection rate of sentinel lymph nodes (SLN) of the two tracers was compared.Results The detection rate of SLN of methylene blue group and carbon nanoparticles suspension injection group was both 100.0％.In methylene blue group,22 cases were detected with SLN.There were 48 SLNs in total with an average of 2.2,and the recognition rate was 88.0％.Five patients were found lymph node metastasis.In carbon nanoparticles suspension injection group,23 cases were detected with SLN.There were 50 SLNs in total with an average of 2.3,and the recognition rate was 92.0％.Four patients were found lymph node metastasis.No obvious side effects were occurred.Conclusion Methylene blue and carbon nanoparticles suspension injection have fairly high recognition rate and detection rate for SLN in laparoscopic radical resection of cervival cancer,and they are safe and worthy of clinical application.%目的 探讨亚甲蓝和纳米炭混悬注射液两种不同淋巴结示踪剂在腹腔镜下宫颈癌根治术中的应用效果.方法 收集2015年至2016年50例被确诊为宫颈癌的患者,随机分为亚甲蓝组(n=25)和纳米炭混悬注射液组(n=25).比较两种不同淋巴结示踪剂在宫颈癌根治术中对前哨淋巴结(SLN)的检出效果.结果 亚甲蓝组和纳米炭混悬注射液组对SLN的检出率均为100.0％.亚甲蓝组25例患者中有22例检出SLN,共48枚,平均2.2枚,识别率为88.0％,5例发现淋巴结转移;纳米炭混悬注射液组25例患者中有23例检出SLN,共50枚,平均2.2枚,识别率为92.0％,4例发现淋巴结转移.两组患者均无明显不良反应.结论 亚甲蓝和纳米炭混悬注射液在腹腔镜下宫颈癌根治术中对SLN有较高的识别率和检出率,且安全性高,值得临床推广.