新疆哈萨克族人血清同型半胱氨酸分布特征及高同型半胱氨酸血症流行特征﹡

摘要

目的：掌握新疆哈萨克族人群血清同型半胱氨酸(Hcy)的分布特征及高同型半胱氨酸血症（HHcy）流行特征。　　方法：采取分层整群随机抽样的方法，调查新疆新源县哈萨克族人群共1003人，将其按照性别分为男性（n=433）和女性（n=570）；按照年龄划分为五个年龄层，即25~34岁组（n=333）、35~44岁组（n=306）、45~54岁组（n=230）、55~65岁组（n=90）和>65岁组（n=44）。进行问卷调查、体格检查和血生化指标检测。　　结果：调查人群的Hcy几何均数为13.3μmol/L，男性高于女性（16.0μmol/L vs 11.6μmol/L）；按年龄层，Hcy水平随着年龄增长而增高（P<0.05），除＞65岁，其余4个年龄层男性Hcy水平均高于女性；调查人群HHcy患病率为31.5%；患病率男性明显高于女性，（49.9% vs 17.5%）；调查人群H型高血压患病率为35.1%，男性高于女性（44.3% vs 28.1%）；高血压患者中H型高血压患病率为87.6%，男性高于女性（95.0%vs 80.0%）。差异均有统计学意义（P<0.001）。　　结论：新疆哈萨克族人群中Hcy水平存在性别、年龄差异，哈萨克族人群HHcy患病率高于全国平均水平，哈萨克族人群及高血压患者中H型高血压患病率亦高于全国平均水平，需要进行危险因素调查本地区哈萨克族与HHcy相关的危险因素，采取有效的措施进行社区干预，以提高哈萨克族人群的健康水平。%Objective: To observe the characteristics of serum homocysteine (Hcy) distribution and the epidemiological characteristics of high serum level of Hcy (HHcy) in Kazakh population. Methods: The stratiifed cluster random sampling method was used to investigate 1003 kazakh individuals in Xinyuan county of Xinjiang including 433 male and 570 female, and they were individuals into 5 age groups:①(25-34) years, n=333,②(35-44) years, n=306, ③(45-54) years, n=230, ④(55-65) years, n=90, ⑤>65 years, n=44. The questionnaire survey, physical check-up and blood biochemical examination were performed and compared among different groups. Results: ① The geometrical mean of Hcy was 13.3μmol/L, and the male was higher than female as 16.0μmol/L vs 11.6μmol/L. ②By age stratiifcation, the serum levels of Hcy elevated with the increased age accordingly. Except for those with the age>65 years, the serum levels of Hcy were all higher in male than female in other 4 age groups. ③The average rate of HHcy prevalence was 31.5%, and the male was higher than female as 49.9%vs 17.5%.④The average rate of H type hypertension prevalence was 35.1%, and the male was higher than female as 44.3%vs 28.1%. There were 87.6%of H type hypertensive patients with H type hypertension, and the male was higher than female as 95.0%vs 80.0%, all P<0.001. Conclusion: The serum levels of Hcy were different from gender and age; the prevalences of HHcy and H type hypertension were higher in Kazakh population at Xinyuan county of Xinjiang. Community intervention should be conducted to improve the public health condition in Kazakh population.