绝经后女性催乳素裂解与高血压及心功能不全关系的研究

摘要

Objective: To investigate the relationship between prolactin (PRL) cleavage and the occurrence of hypertension, heart failure (HF) in post-menopausal female patients. Methods: A total of 216 post-menopausal female subjects were enrolled in our study and they were divided into 3 groups: Hypertension group,n=80 patients with essential hypertension, Hypertension + HF group,n=76 and Control group,n=60 post-menopausal women form regular physical examination. The full length (23 kD PRL), 16 kD PRL fragment, lipid peroxide (LPO), total antioxidant status (TAS), left ventricular ejection fraction (LVEF), NT-proBNP, creatinine, uric acid, fasting blood glucose (FBG) and BMI were examined and compared among different groups. Results:①There were no real differences in age, creatinine, uric acid, FBG and BMI among groups,P>0.05.②Compared with Control group, Hypertension group had increased LPO and decreased TAS; compared with Control group and Hypertension group, Hypertension + HF group had increased LPO and decreased TAS.③Compared with Control group, Hypertension + HF group showed lower level of 23KD PRL, higher level of 16KD PRL and the higher ratio of 16KD PRL/23KD PRL,P<0.05-0.01.④Pearson correlation analysis indicated that LPO was negatively related to 23KD PRL (r=-0.784,P<0.01), positively related to 16KD PRL (r=0.807, P<0.01); TAS was positively related to 23KD PRL (r=0.768, P<0.01), negatively related to 16KD PRL (r=-0.777P<0.01); 23KD PRL was positively related to LVEF (r=0.852, P<0.01), negatively related to NT-proBNP (r=-0.832P<0.01); 16KD PRL was negatively related to LVEF (r=-0.850,P<0.01), positively related to NT-proBNP (r=0.814,P<0.01). Conclusion: PRL cleavage was highly related to the occurrence of hypertension and HF in post-menopausal female patients.%目的：探讨绝经后女性催乳素裂解与高血压及心功能不全的关系，为其发病机制和防治策略提供新的理论依据。　　方法：本研究共入选受试者216例，其中甘肃省人民医院心内科绝经后女性高血压患者156例，包括高血压患者（高血压组）80例，高血压合并心功能不全患者（观察组）76例；选取同期体检健康的绝经后女性（对照组）60例。检测指标包括全长催乳素（23 kD PRL）、催乳素片段（16 kD PRL）、脂质过氧化物（LPO）、总抗氧化能力（TAS）及左心室射血分数（LVEF）、N末端B型利钠肽原（NT-proBNP）、肌酐、尿酸、空腹血糖及体重指数（BMI），并进行统计分析。　　结果（：1）各组间在年龄、肌酐、尿酸、空腹血糖及BMI等方面无显著性差异（P>0.05）。（2）高血压组LPO显著高于对照组，TAS显著低于对照组；观察组LPO显著高于对照组和高血压组，TAS显著低于对照组和高血压组（P<0.05）。（3）观察组23kD PRL显著低于对照组，16 kD PRL、16 kD PRL/23 kD PRL显著高于对照组。差异均有统计学意义（P<0.05~0.01）。（4）经Pearson相关分析，LPO与23kD PRL呈负相关（r=-0.784P<0.01），与16 kD PRL呈正相关（r=0.807P<0.01）；TAS与23 kD PRL呈正相关（r=0.768P<0.01），与16 kD PRL呈负相关（r=-0.777P<0.01）；23 kD PRL与LVEF呈正相关（r=0.852 P<0.01），与NT-proBNP呈负相关（r=-0.832P<0.01）；16 kD PRL与LVEF呈负相关（r=-0.850P<0.01），与NT-proBNP呈正相关（r=0.814 P<0.01）。　　结论：催乳素裂解与绝经后女性高血压及心功能不全高度相关。